WFDC2 and pancreatic intraductal papillary-mucinous neoplasm: As shown in Table 4, At a fixed SP of 80% and including sex and age as cofactors, the two-marker panel of HE4 and CEA significantly improved SN in separating IPMN from CP in comparison to that of CA19-9 alone (74% vs. 21%, p < 0.0001).