The three best biomarkers to separate IPMN from CP were CA-125 (0.652 (0.548–0.756)), Tie-2 (0.630 (0.525–0.734)), and HE4 (0.588 (0.481–0.696)). The gene discussed is MUC16; the disease is pancreatic intraductal papillary-mucinous neoplasm.