Serum levels of CA-125 and Tie-2 were significantly lower in IPMN compared with CP patients (CA-125 at p < 0.01 and Tie-2 at p < 0.05); however, there was no significant difference in serum levels of other biomarkers between IPMN and CP patients. Here, TEK is linked to pancreatic intraductal papillary-mucinous neoplasm.