The three best biomarkers to separate PDAC from IPMN were CA-125 (0.799 (0.731–0.868)), CA19-9 (0.766 (0.699–0.833)), and CEA (0.671 (0.586–0.757)). This evidence concerns the gene MUC16 and pancreatic intraductal papillary-mucinous neoplasm.