Furthermore, the same two-marker panel of CA19-9 (p = 0.0097) and CA-125 (p = 0.0277) remained in the model that had an AUC of 0.805 (0.720–0.891), which was greater than the individual biomarkers for early stage PDAC versus IPMN (p value: CA-125 at 0.0966 and CA19-9 at 0.0113). Here, MUC16 is linked to pancreatic intraductal papillary-mucinous neoplasm.