It should be noted that Wang et al. identified PLAGL2 as well as MAPKAPK5-AS1 as the direct targets of miR-154-5p and the MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop that is responsible for progression and metastasis of hepatocellular carcinoma [96]. This evidence concerns the gene PLAGL2 and hepatocellular carcinoma.