FLT3 and myeloid leukemia: In this study, we revealed that pyrvinium pamoate could not only inhibit the FLT3 signaling pathway, but also target mitochondria and induce cellular stress responses; these ultimately inhibited cell proliferation and triggered the apoptosis of Molm13 and derived Molm13 (Molm13-XR) myeloid leukemia cells (Supplementary Figure S1).