APOE and atherosclerosis: Here, we present a longitudinal study that uses simultaneous assessments of flow, PWV, all WSS components and the OSI in the aortic arch, based on 4D phase contrast MRI (PC-MRI) [7,23] for studying global and local hemodynamic changes in ageing wildtype (WT) and atherosclerosis-prone Apolipoprotein E-deficient (Apoe)−/− mice during plaque progression.