To improve our understanding of these epigenetic factors, the present study evaluated the EZH1/2 mutation status in a cohort of 33 monomorphic epitheliotropic intestinal T-cell lymphomas (MEITL) by next generation targeted sequencing and detected EZH1/2 and H3K27me3 expression levels by immunohistochemistry in 46 T-cell lymphomas. The gene discussed is EZH1; the disease is T-cell non-Hodgkin lymphoma.