Counterintuitively to our correlative study, in which EZH2 and EZH1 expression was not associated and low EZH1 expression conferred a poor prognosis, mechanistic studies revealed that dual inhibition of EZH1 and EZH2 is required for strong lethality in lymphomas due to increased EZH1 occupancy with focal H3K27me3 upregulation [12]. This evidence concerns the gene EZH1 and lymphoma.