Furthermore, our finding indicating that Low BMI, and lnc-IL7R, with concomitant high PM2.5, and SO2 levels is pathognomonic of exacerbated/severe COPD-E in New Taipei City, Taiwan, corroborates the conclusions of a recent comprehensive analysis of two large cohorts that a panel of disease-related variables improve predictive value for disease outcomes, compared with lone clinical variables and individual biomarkers [33]. The gene discussed is IL7R; the disease is chronic obstructive pulmonary disease.