For the first time, to the best of our knowledge, the present study demonstrated that per geospatial levels, areas with high BMI and lnc-IL7R but low ambient PM2.5, PM10, and SO2 were associated with fewer and ameliorated COPD-E cases, while high PM2.5, PM10, and SO2 but low BMI and lnc-IL7R characterized regions with more COPD-E cases and indicated disease exacerbation. Here, IL7R is linked to chronic obstructive pulmonary disease.