IL7R and pulmonary emphysema: We showed that ambient air pollutants (PM2.5, PM10, NO2, SO2, THC, O3), epigenetic (lnc-IL7R), anthropometric (Age, BMI), lifestyle (smoking history, pack-year), and geospatial components (longitude and latitude of participants’ residential addresses) all contribute differentially to emphysema (COPD-E) severity (%LAA-950insp).