Alternatively, it cannot be excluded, that a loss of ACE2 in cancers derived from a normal progenitor cell that physiologically expresses ACE2—such as kidney and colon epithelium—may reflect cancer cell dedifferentiation and thus be related to unfavourable tumour behaviour even if the diminished ACE2 expression does not contribute to the altered biologic behaviour of cells. Here, ACE2 is linked to neoplasm.