In terms of adipogenesis and the physical stiffness of the 3D spheroids, since we showed that these changes were more evident in the later (Days 5 to 7) rather than the earlier (until Day 5) period during the course of the 3D cultures [8,16], the unexpected results for Pparγ in the expression of Ap2 observed in cases of switching from OMD or Buta to BIM-A, which was assumed to be due to the effects of a mono-treatment, may have been caused by some unknown cross-linkages between EP2 and PGF2α-ags receptors that are related to signaling (Table 1). The gene discussed is PPARG; the disease is occult macular dystrophy.