To further verify whether SYNE1-rs9479297 could serve as a marker to predict the occurrence of HCC/TCC DPC, the genotypic distributions were compared among four independent cohorts of patients with HCC/TCC DPC (n = 101), HCC alone (n = 265), TCC alone (n = 44), and non-HCC/non-TCC (n = 148). This evidence concerns the gene SYNE1 and hepatocellular carcinoma.