Since renal sympathetic nerve activity (RSNA) substantially modulates renal vascular reactivity to vasoactive agents, particularly in ANG II-dependent models of hypertension [23,24], the beneficial effects of RDN on RBF in ACF TGR could be mediated by abolishing, or at least by diminishing, exaggerated renal vascular responsiveness to ANG II. Here, AGT is linked to hypertensive disorder.