In the SARC028 trial, which investigated the efficacy of pembrolizumab in advanced sarcoma, PD-L1 positivity, infiltrating lymphocyte density, and the abundance of tumour-infiltrating macrophages correlated with the response to monotherapy in undifferentiated pleomorphic sarcoma and dedifferentiated pleomorphic liposarcoma [31]. The gene discussed is CD274; the disease is neoplasm.