STAT3 and prostate cancer: In another study about the role of pimozide in prostate cancer treatment, pimozide reduced cell proliferation and migration by increasing the formation of reactive oxygen species (ROS) in PC3 and DU145 prostate cancer cell lines in vitro and in vivo in TRAMP mice [58], while in the study of Cai et al., pimozide had a similar effect in osteosarcoma U2OS cell lines by downregulating the expression of catalase, probably mediated through inhibition of the activity of signal transducer and activator of transcription 3 (STAT3) [59].