IFNG and glioblastoma: Another penfluridol-mediated inhibition of GBM cell (U87MG) proliferation in vivo was reported by Ranjan et al., describing a reduction of immune suppressive cells (T regulatory cells, myeloid-derived suppressive cells), upregulation of tumor-killing M1 macrophages, and decreased chronic inflammation biomarkers (CC14, IFNγ) in mice subcutaneously injected with U87MG GBM cells [90].