STAT3 and central nervous system cancer: Finally, Kim et al., using cell culture (in vitro) and xenografted mice (in vivo), supported that ARP induced apoptosis-mediated cytotoxicity and migration suppression by direct inhibition of Src oncogenic tyrosine and therefore inhibition of the signaling cascade molecules (phosphorylated phosphatidylinositide 3-kinase, STAT3, and Akt), all involved in glioma progression [150].