Kurita et al. found that chlorpromazine inhibits the interaction between RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF), a transcription repressor overexpressed in medulloblastoma, and the paired amphipathic helix domains (PAH1) domain of mSin3 thus inhibiting the in vitro growth of medulloblastoma DAOY cell lines [45]. The gene discussed is REST; the disease is medulloblastoma.