AKT1 and hepatocellular carcinoma: Moreover, epidemiological studies have shown that quetiapine reduces the risk of hepatocellular carcinoma development in patients with schizophrenia [131], while according to Lee et al., quetiapine inhibited cell proliferation and migration of Hep1 and Hep3B HCC cancer cell lines and induced their apoptosis via activation of intrinsic and extrinsic apoptotic pathways and simultaneous reduction of expression of anti-apoptotic proteins such as XIAP and survivin via inhibition of the ERK/AKT signaling pathway [132].