CASP3 and breast carcinoma: Regarding its anticancer properties, Badran et al., in their in vitro studies in MCF-7 cells (breast cancer cell line), observed inhibition of cell proliferation by cell cycle arrest in subG0/G1 phase and subsequently the induction of apoptosis (downregulation of anti-apoptotic genes BCL2L1, C-myc and upregulation of pro-apoptotic genes BCL-10, BAK, active caspase-3 and caspase-9) [145].