The antipsychotic effect of typical antipsychotics is primarily mediated through inhibition of the D2 dopamine receptors (DRD2) in the mesolimbic dopaminergic pathway, the main brain pathway hyperactivated in patients with positive psychotic symptoms such as hallucinations and delirium, while atypical antipsychotics work by inhibiting DRD2 and serotonin receptors, most commonly the 5-HT2A subtype [6]. Here, DRD2 is linked to delirium.