In a recent study, Rai et al. found that chlorpromazine caused the reduction, both in vitro and in vivo, in the levels of clathrin assembly lymphoid myeloid leukemia (CALM) protein and disturbed the subcellular localization of acute myeloid leukemia (AML)-mutated receptor tyrosine kinases (RTKs) such as FLT3-ITD and KIT-D816V, while sparing the non-mutated RTKs [47]. This evidence concerns the gene FLT3 and acute myeloid leukemia.