MDM2 and neoplasm: Finally, Patil et al., based on their own in vitro studies, proposed that FSP acts as a p53-MDM2 inhibitor by binding to the p-53 binding pocket of the MDM2 protein, causing activation of the tumor suppressor protein p53 and subsequent inhibition of tumor growth in human colon cells and several other human tumor cell lines in the NCI60 cell line panel [73].