RB1 and hepatocellular carcinoma: Shi et al., in their in vitro studies, found that FSP attenuated viability and proliferation of HCC (HepG2, Huh cells) cell lines by reducing the expression of CDK2, Rb, pho-CDK2, pho-Rb, and cyclin E, all responsible for the transition from the G1 to S phase of the cell cycle, thus arresting the cancerous cells in G2 phase and subsequently inducing apoptosis.