AKT1 and metabolic dysfunction-associated steatotic liver disease: RTKs are known to be involved in the development and progression of NAFLD via various pathways such as PI3K/AKT/mTOR, RAS/ERK, Janus Kinase (JAK)/signal transducer and activator of transcription proteins (STAT3), FXR/SHP, etc. These pathways present as cascading signals from RTKs to effector molecules such as nuclear receptors, transcriptional factors or other vital intermediates controlling lipid metabolism, oxidative stress, inflammation and also fibrosis.