PNPLA3 and metabolic dysfunction-associated steatotic liver disease: For instance, Single Nucleotide Polymorphisms (SNPs) in the gene encoding patatin-like phospholipase domain-containing protein 3 (PNPLA3) [8], transmembrane 6 superfamily 2 [9,10], membrane bound O-acetyltransferase domain containing 7 [11,12] have been associated with NAFLD.