In a study conducted by Bárcena C. et al. (2015), the authors used both a genetic model of Axl deficiency (Axl KO) and a chemical inhibition of AXL by BGB324 and observed reduced HSC activation, thus, proving the role of Gas6/AXL pathway in fibrosis development [70]. Here, AXL is linked to hyperinsulinemic hypoglycemia, familial, 4.