CCL2 and hepatocellular carcinoma: For example, in hepatocellular carcinomas, it has been found that CCL2, released by oncogene-induced senescent hepatocytes, may result in the attraction of CCR2+ immature myeloid cells, which differentiate into macrophages to clear precancerous senescent hepatocytes, but may also promote tumour growth by inhibiting NK cells in the presence of established hepatocellular carcinoma cells [40].