Orthotopic rodent and murine bladder tumors treated with BCG (Pasteur, Connaught and Tice) were shown to recruit both CD4 [17,18] and CD8 [18,19] T cells that recognized ‘tumor antigens’ overexpressed in the tumor cell line [18] and BCG antigens [18,19,20]. This evidence concerns the gene CD8A and neoplasm.