CHGA and Hypertension: Recent preclinical data corroborate that catestatin acts as an autocrine attenuator of cardiac inflammation in hypertension by reducing macrophage inflammation in the heart as catestatin-KO mice did not only develop a hypertensive phenotype, but also showed marked left ventricular hypertrophy, macrophage infiltration of the heart and adrenal glands, as well as elevated levels of proinflammatory cytokines and catecholamines [54].