CHGA and hydrops fetalis: In line with the pathophysiological background, clinical studies showed that levels of ChgA were elevated in the peripheral blood of patients with chronic HF (5–10-fold increase), dilated cardiomyopathy/hypertrophic cardiomyopathy (2.5-fold increase), and MI patients with symptoms of HF (0.61 vs. 0.49 nM), correlating with both mortality and poor outcomes [14,61,62,63,64,65,66].