To study MMP-2 and MMP-7 expression and the effect of anti-EGFR and rapamycin in vivo, we took advantage of a mouse LAM model in which inhaled LAM/TSC cells in immunodeficient female athymic nude mice caused the formation of multiple lung nodules and enlarged alveolar spaces [16]. The gene discussed is MMP2; the disease is lymphangioleiomyomatosis.