Furthermore, exosomes isolated from HUVECs cultured under hyperglycemic conditions promoted endothelial cell wound healing as well as the expression of phosphorylated endothelial nitric oxide synthase, human cationic amino acid transporter type 1 (hCAT-1), and ICAM-1 in HUVECs cultured in normal glucose concentrations, imitating the destructive effects of hyperglycemia [179]. This evidence concerns the gene NOS3 and Hyperglycemia.