Our studies confirmed that NaBt and NaVPA inhibited the HDAC activity (Figure 10), leading to upregulated proapoptotic Bad and Bax proteins levels, with a concomitant downregulation of antiapoptotic Bcl-2 protein in U-87 and U-251 GBM cell lines (Figure 11). This evidence concerns the gene HDAC9 and glioblastoma.