On the one hand, MBD2 depletion protected against bleomycin-induced pulmonary fibrosis by a significant attenuation of TGF-β1 production, as well as a significant reduction in the accumulation of CD206+CD68+F4/80+ macrophage (Table 1), but not of M1, in the lung. Here, TGFB1 is linked to pulmonary fibrosis.