The functional role of M2 macrophages in intestinal wound healing was reported by our group, where we showed that STAT6−/− mice exhibited delayed wound healing in acute 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-colitis associated with a reduced number of M2a macrophages and administration of M2a macrophages accelerated the intestinal regeneration and ameliorated acute colitis. The gene discussed is STAT6; the disease is colitis.