In line with these findings, in a KO murine model for MMP-28 of bleomycin-induced pulmonary fibrosis, they observed that the absence of MMP-28 was related to greater recovery of body weight, greater survival, and a reduction in polarization towards M2 characterized, in part, by a reduction in TGF-β1 expression and collagen synthesis. This evidence concerns the gene TGFB1 and pulmonary fibrosis.