Finally, a current and elegant study has demonstrated that TGF-β is released through the ERK signaling pathway by liver macrophages classified as F4/80highCD11blowCLEC4F+ KCs, when they are activated with c-Mer tyrosine kinase (MERTK), inducing HSC fibrotic effects in NASH [110]. The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatohepatitis.