Indeed, an interesting study demonstrated that in this CCl4-fibrosis animal model, KCs through a DAMP known as high-mobility group box-1 (HMGB1) could increase the expression of collagen type I alpha1 chain (COL1A1) by HSCs via phosphorylation of mitogen-activated protein kinase (MAPK). This evidence concerns the gene HMGB1 and fibrosis.