TLR4 and inflammatory bowel disease: Another protein-coding gene which plays an important role in the recognition of pathogens molecular patterns is Toll Like Receptor 4 (TLR4), renowned for its implication in the pathogenesis of IBD [25]; recent findings have also highlighted a role for the CD14 gene for its protective effect of IBD, because it acts as an orchestrator of the intestinal mucosal barrier homeostasis [26].