KDM5B is required for HSC self-renewal in mice [49,50] and is expressed in human CD34+ cells and in the CML cell line K562, as well as in several AML cell lines (Kasumi-1, KG-1, HEL, HL60, MonoMac-60) (Table 1) [46]. The gene discussed is KDM5B; the disease is acute myeloid leukemia.