Mann et al. [150] presented evidence that those with severe COVID-19 have a shift in the neutrophil-to-T cell ratio, elevated serum IL-6, MCP-1, and IP-10, and modulation of CD14+ monocyte phenotype and function including poor induction of the COX-2 enzyme, implying suboptimal production of PGE2. This evidence concerns the gene IL6 and COVID-19.