A deficiency of GLA, DGLA, AA, EPA, and DHA due to low activity of desaturases increases the rigidity of cell membrane, as seen in those with diabetes mellitus, hypertension, and coronary heart disease, who have decreased plasma and tissue concentrations of GLA, DGLA, AA, EPA, and DHA [8,9,10,11,12,18,19,20,21,22]. The gene discussed is GLA; the disease is diabetes mellitus.