Both pre-treatment (exposing the RIN5F cells initially to resolvin/protectin/LXA4 and then to alloxan) and simultaneous treatment (RIN5F cells were exposed to LXA4/resolvin/protectin and alloxan at the same time) studies showed that LXA4 is the more potent compared to resolvins and protectins in preventing alloxan-induced cytotoxicity to RIN5F (rat insulinoma) cells in vitro [17]. This evidence concerns the gene CD59 and pancreatic insulinoma.