Other analyses of siblings with symptoms of vitamin D deficiency and rickets by al Mutair et al. detected two CYP2R1 mutations, NC_000011.10:g.14885775C>T (c.367+1G>A) and NC_000011.10:g.14880371dup (p.Leu257fs). This evidence concerns the gene CYP2R1 and vitamin D deficiency.