AGT and brain ischemia: Under conditions of cerebral ischemia–reperfusion, it has been observed that AT1R antagonism may reduce the infarct size in both normotensive and hypertensive rats [12], indicating that Ang II could play a role in the mechanisms linked to cerebral damage, where the predominance of Ang II in Ang 1-7 activity may trigger arteriolar constriction and an increase in arteriolar resistance.