ANGPT1 and ischemic stroke: These data indicate that the effects of Ang II and Ang 1-7 were opposite under hypoperfusion and reperfusion conditions, confirming the suggested competition between the RAS end final molecules, which are effective in exacerbating or preventing vascular damage under pathophysiological conditions, as also observed by Arroia and coworkers studying the different effects of Ang II and Ang 1-7 in ischaemic stroke [38].