Furthermore, binding of deleted in malignant brain tumors 1 (DMBT1), a tumor-suppressor gene, with lncRNA colorectal neoplasia differentially expressed (CRNDE), and cellular inhibitor of apoptosis protein 1 (c-IAP1) was found to promote PI3K-AKT signaling pathway in GBC [95]. The gene discussed is AKT1; the disease is neoplasm.