FLG and Alzheimer disease: Wallmeyer studied the effects of TSLP on a mice knock out model for the gene-encoding filaggrin, one of the main factors involved in the pathogenesis of AD; interestingly, the effect of TSLP on the activation of dendritic cells and the subsequent activation of the Th2 response is well known, but what this research group found is that the effects of TSLP act upon T lymphocytes, switching the immune response from Th1/Th17 to Th2/Th22 without the aid of dendrocytes [42].