PLOD2 and metastatic malignant neoplasm in the lymph nodes: However, upregulated PLOD2 in FLCs (PLOD2FLCs) were positively correlated with worse tumor differentiation (p < 0.001), worst pattern of invasion (WPOI) (p < 0.001) and high risk of lymph node metastasis (LNM) (p < 0.001) (Table 1 and Figure 4a,c).