This effect is in accord with the results of a rodent study in which SIRT2 repressed the aging-related and AngII-induced cardiac hypertrophy, whereas the loss of SIRT2 expression blunted this protection against cardiac hypertrophy, an effect likely caused by the failure to activate the liver kinase B1-AMPK pathway [145]. The gene discussed is PRKAA1; the disease is cardiac hypertrophy.