In this context, linagliptin, icariin, and rolipram deserve further studies, which could pave the way to the use of these chemicals for the treatment of autoimmune diseases, cancers, and even severe COVID-19 cases, since the latter medical condition is characterized by hyperinflammation (cytokine storm) where simultaneous inhibition of caspase-1 and TNF-alpha could be essential for an efficacious treatment. This evidence concerns the gene TNF and cancer.