An important aspect to highlight here is that both caspase-1 and TNF-alpha are essential in the development of the hyperinflammatory physiological reaction known as cytokine storm, which is present in viral infections caused by coronaviruses [14,15], including the causal agent of the current COVID-19 pandemic (SARS-CoV-2) [14,15,16]. This evidence concerns the gene TNF and viral infectious disease.