Further studies have suggested that baicalein isolated from methanolic extract of roots of Scutellaria baicalensis Georgi could inhibit cyclooxygenase-2 in rodent brain resulting in reduced brain level of prostaglandin E2 and act as strong anti-oxidant, which also helps in prevention of the chronic mild stress-induced depression-like behavior in mice [56]. The gene discussed is PTGS2; the disease is major depressive disorder.