The cut-off values for UPIIIa (BPH-plasma), UPIIIa (UTI-plasma), UPIIIa (BPH-urine), UPIIIa (UTI-urine), UPII (BPH-urine) and UPII (UTI-urine) were 1.46 ng/mL, 1.29 ng/mL, 1.26 ng/mg creatinine, 1.17 ng/mg creatinine, 0.13 ng/mg creatinine, 0.11 ng/mg creatinine, respectively (Figure 2). This evidence concerns the gene UPK3A and benign prostatic hyperplasia.