KEAP1 and hepatocellular carcinoma: NRF2 is a vital regulator of the antioxidant response, whose overexpression inhibits apoptosis and contributes to chemoresistance in several cancers, and Sun et al. found that the status of NRF2 is a key factor that determines the therapeutic response to ferroptosis-targeted therapies in HCC cells, while the p62-Keap1-NRF2 pathway protects against ferroptosis in HCC cells [52,53,54].