ALPI and hyperinsulinemic hypoglycemia, familial, 4: IAP deficiency has been linked to plethora of conditions such as IBD, type 2 diabetes, ischemic heart disease, aging, necrotizing enterocolitis, and metabolic syndrome, among others [1,2,3,4].Supplementation with IAP has been tested in clinical and pre-clinical studies for its protective role in various diseases.