However, the downregulation of Kv1.3 expression was not observed in human tissue: elevated Kv1.3 channel expression has been observed in human postmortem AD brains by immunohistochemistry and by western blot analysis, and the elevation is limited to microglia, especially in those associated with amyloid plaques, suggesting that Kv1.3 could still represent a relevant microglial target in AD [97]. This evidence concerns the gene KCNA3 and Alzheimer disease.