SMAD7 and Hypertension: On the other hand, miR-29b had its expression reduced in a mouse model of Ang-II-induced hypertension, increasing the expression of cholagen-1 (COL-I), transforming growth factor-β (TGF-β), α -SMA, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), with reduced expression of the mothers against decapentaplegic homolog 7 (SMAD7) gene, inducing LVH.