PDE5A and cardiac hypertrophy: On the other hand, Ang-II-induced pressure overload in rats reduced the expression of miR-19a and miR-19b, increasing the expression of phosphodiesterase 5A (PDE5A), generating LVH, including, as the authors show in the same study, that a model of transgenic mouse overexpressing miR-19a and miR-19b reduced PDE5A expression, decreasing cardiac hypertrophy [55], demonstrating that an expression pattern response of miRNAs in cell culture can be quite different from the response in animal models.