AKT1 and obesity due to melanocortin 4 receptor deficiency: According to the PPI network analysis of hispidulin anti-obesity targets (Figure 2B), SRC (proto-oncogene tyrosine-protein kinase Src), EGFR (epidermal growth factor receptor), and AKT1 (AKT serine/threonine kinase 1) were the top three genes based on the degree (Table 3).