Indeed, among these factors, the tumor microenvironment consists of VEGF (Vascular Endothelial Growth Factor), bFGF (basic Fibroblast Growth Factor), and PDGF (Platelet-Derived Growth Factor), cytokines, small non-coding RNAs which strongly acts to promote angiogenesis mainly in a hypoxic environment [3]. This evidence concerns the gene VEGFA and neoplasm.