PRKAA1 and T-cell acute lymphoblastic leukemia: For example, AMPK has been demonstrated to inhibit cell proliferation via inhibition of rapamycin complex (mTOR) T-cell acute lymphoblastic leukemia [39], inhibit endothelial cell proliferation via elevation of p21 and p27 expression [40], and block the growth of the HepG2 cell line via phosphorylation of p53 [41], especially the role of AMPK in preadipocyte proliferation.