In our facility, we found that the inhibition of LDHA failed to block lactic acid production or alter glycolysis in diverse cancer cell line models; including (1) cells with LDHA silenced genes using lentiviral shRNA and [7] (2) applying confirmed human recombinant LDHA inhibitors derived from a high-throughput screening, which had no effect on lactic acid produced, glucose consumed, or ATP when tested in vitro [8,9]. The gene discussed is LDHA; the disease is cancer.