By analyzing the TCGA ovarian cancer dataset generated by GEPIA, a significant albeit very weak correlation was observed between high expression of GLS and upregulation of immunosuppressive genes including PD-L1 (CD274), PD-1 (PDCD1), PD-L2 (PDCD1LG2), CTLA4, and LAG3 (Supplementary Figure S1), suggesting the potential effects of GLS on immunosuppressive microenvironment in ovarian cancer. The gene discussed is CTLA4; the disease is ovarian cancer.