AKR1C3 and gestational diabetes: Since the HSD17B3 is a testicular enzyme, while the AKR1C3 is widely expressed in various tissues and explicitly in adipocytes (and further tissues such as the digestive tract, smooth muscle, pancreas and to a much lesser extent also in adrenal zona reticularis (ZR)), the aforementioned data point to the reduced AKR1C3 activity in the GDM+ group.