Interestingly, the book of Fasken et al. (2020) provides a summary of the most common variants in DIS3 which all occur in heterozygous state, are associated with multiple myeloma, and seem to have mild effects only, while Tomecki et al. (2014) suggests the potential lethality of mutations in the PIN domain of DIS3. This evidence concerns the gene DIS3 and AL amyloidosis.