For example, several tumor antigens that have been used for targeted therapies in human cancers are also identified in canine malignancies, including EGFR, HER2, VEGFR2, CD20, podoplanin, PD-1, and PD-L1 [16,41,42,43,44,45,46,47,48,49]. The gene discussed is CD274; the disease is neoplasm.