AURKA and breast cancer: Binding of NEDD9 to AURKA, which appears to involve NEDD9 serine (Ser) 296 and the N-terminal domain of AURKA [117,118], suppresses proteasomal degradation of AURKA promoted by the ubiquitin ligase anaphase-promoting complex/C (APC/C) in MDA-MB-231 cells, a human breast cancer cell line [118].