This subunit, encoded by PSMB8 gene, has a wide range of expression among different cancers, which have been evaluated in non-small cell lung carcinoma (NSCLC), renal cell carcinoma, glioma, colorectal cancer, triple-negative breast carcinoma (TNBC), laryngeal, and hypopharyngeal carcinoma [21,22,148,149,150,151]. This evidence concerns the gene PSMB8 and colorectal cancer.