In elderly HGSOC, mutations in the genes that are involved in the Ras and or PIK3CA signaling pathways were detected in nine samples (15%), including the genes KRAS and BRAF (each one in 1 tumor); PIK3CB and MTOR (each one in 2 tumors); and NF1 (in three different samples). This evidence concerns the gene PIK3CB and neoplasm.