TTN and MUC16 code for two of the longest known proteins in the human genome, with 35,992 and 14,508 amino acids, respectively, and are frequently affected in a high percentage of tumor types, i.e., 24.49% (TTN) and 15.21% (MUC16) (COSMIC database, available at https://cancer.sanger.ac.uk/cosmic/gene/analysis; accessed on 27 May 2020). This evidence concerns the gene TTN and neoplasm.