Thus, in obesity, while the increase in SAT is regarded as protective, by improving insulin sensitivity and decreasing the risk of developing type 2 diabetes, the accumulation of visceral fat is associated with metabolic disease and its harmful sequelae (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, atherosclerosis, hepatic steatosis, and cancer) [5]. Here, INS is linked to type 2 diabetes mellitus.