EGFR and non-small cell lung carcinoma: Osimertinib is a third-generation EGFR TKI and the current standard of care for EGFR mutant tumors, and it was found to have an 80% objective response rate (ORR) in a phase-3 trial of previously untreated EGFR mutant NSCLC [5], suggesting intrinsic mechanisms of resistance to EGFR inhibition.