NRF2 is the master regulator of the cellular antioxidant response, and disruptions in the KEAP1-NRF2 signaling axis were found to provide a growth advantage to lung cancer cells as well as resistance to chemotherapy through control of a broad range of cellular functions, including redox homeostasis, metabolism, survival, and proliferation [132,133]. The gene discussed is KEAP1; the disease is lung carcinoma.