NSC-34 cell lines are mouse motor neuron-like cells containing human SOD1 (NSC-34/hSOD1wt) and SOD1 (G93A) gene mutation and are widely used for the study of ALS disease mechanisms and also to discover the therapeutically effective drug regimen in motor neurodegeneration [32,35]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.